Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices

Phase 4 Terminated 34 enrolled Medical University of South Carolina Ohio State University · collab University of Florida Health · collab University of Texas Southwestern Medical Center · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

This study evaluates the safety and efficacy of 24-hour vs 72-hour octreotide infusion after variceal banding in cirrhotic patients with bleeding esophageal varices.

Timeline

Start: 2018-09-19
Primary completion: 2024-12-01
Completion: 2024-12-01

Outcome

Met primary endpoint

Stopped (Enrollment): “Recruitment was severely affected due to COVID, so study was stopped prematurely.”

paper A 24-hr infusion is non-inferior to a 72-hr infusion of octreotide for prevention of re-bleeding in patients with EVH. PMID 39241828 ↗

Publications

Results Allam J, De Melo S, Feagins LA, Agrawal D, Malespin M, Shuja A, Lara LF, Rockey DC. Comparison of 24 vs 72-hr octreotide infusion in acute esophageal variceal hemorrhage - A multi-center, randomized clinical trial. Am J Med Sci. 2025 Jan;369(1):71-76. doi: 10.1016/j.amjms.2024.08.027. Epub 2024 Sep 4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Octreotide	Peptide	—	—