Investigation of Neural Stem Cells in Ischemic Stroke

Summary

A study of stereotactic, intracerebral injection of CTX0E03 neural stem cells into patients with moderate to moderately severe disability as a result of an ischemic stroke.

Timeline

Start

2018-08-31

Primary completion

2020-09-09

Completion

2021-03-02

Outcome

Outcome not reported

Stopped (Business): “Strategic decision to progress stroke disability programme through regional partnerships”

Publications

• Laskowitz DT, Muir KW, Savitz SI, Wechsler LR, Pilitsis JG, Rahimi SY, Beckman RL, Holmes V, Chen PR, Juel L, Koltai D, Kolls BJ. Methodological considerations in PISCES 3: a randomized, placebo-controlled study of intracerebral stem cells in subjects with disability following an ischemic stroke. Front Stroke. 2023 Jul 4;2:1182537. doi: 10.3389/fstro.2023.1182537. eCollection 2023.
• Kolls BJ, Muir KW, Savitz SI, Wechsler LR, Pilitsis JG, Rahimi S, Beckman RL, Holmes V, Chen PR, Albers DS, Laskowitz DT. Experience with a hybrid recruitment approach of patient-facing web portal screening and subsequent phone and medical record review for a neurosurgical intervention trial for chronic ischemic stroke disability (PISCES III). Trials. 2024 Feb 28;25(1):150. doi: 10.1186/s13063-024-07988-z.
• Olmsted ZT, Petersen EA, Pilitsis JG, Rahimi SY, Chen PR, Savitz SI, Laskowitz DT, Kolls BJ, Staudt MD. Toward Generalizable Trajectory Planning for Human Intracerebral Trials and Therapy. Stereotact Funct Neurosurg. 2022;100(4):214-223. doi: 10.1159/000521916. Epub 2022 Feb 7.

Drugs

Indications