Pre-operative Olanzapine as Prophylactic Antiemetic in Oncologic Patients

Phase 2/3 Completed 100 enrolled Cancer Institute of the State of São Paulo

RandomizedParallel-groupTriple-blindPrevention

Summary

Olanzapine has been used as prophylactic antiemetic for chemotherapy induced nausea and vomiting. The project aims to evaluate the efficacy of olanzapine in combination with ondansetron and dexamethasone in patients at high risk of postoperative nausea and vomiting, with previous history of nausea and vomiting induced by prior chemotherapy, submitted to medium and large surgery.

Timeline

Start: 2018-10-01
Primary completion: 2021-02-10
Completion: 2021-02-10

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Olanzapine	Small molecule	10 mg	Oral

Indications

No indication recorded.