Clinical Application of Autologous Mitochondria Transplantation for Improving Oocyte Quality.

Summary

Embryo quality was ranked as one of the most important predictors in determining the success of implantation, while clinically some patients may experience repeated IVF failure due to persistent poor embryo quality.Mitochondria, as the energy factory, is confirmed being a hallmark of quality and developmental potential of human oocytes, and decreased mitochondria copy number was reported to be associated with oocyte aging and dysfunctional mitochondria would be expected to influence the late stages of oocyte maturation and early embryogenesis.The objective of this study is to evaluate the effect of mitochondria transfer from bone marrow mesenchymal stem cell on the quality of oocyte.

Timeline

Start

2018-09

Primary completion

2020-12

Completion

2021-09

Outcome

Missed primary endpoint

paper did not translate into improvements in good-quality embryo rate PMID 42129850 ↗

Publications

• Liu X, Wang D, Jia L, Chen W, Huang R, Fang C, Du C, Yang L, Liu X, Liang X. Autologous bone marrow mesenchymal stem cell mitochondrial transplantation in recurrent assisted reproductive technology failure: a randomized controlled trial. Stem Cell Res Ther. 2026 May 13;17(1):244. doi: 10.1186/s13287-026-05059-5.

Drugs

Indications

No indication recorded.