Postmenopausal Women and Their Endothelium

Phase 2 Completed 37 enrolled Penn State University

RandomizedCrossoverDouble-blindBasic science

Summary

The purpose of this study is to test the effects of a one time dose and 7-days of inorganic nitrate (supplied in the form of beetroot juice) on blood vessel function and resting blood pressure in healthy, postmenopausal women. Participants will drink beetroot juice and a placebo juice on separate visits where blood pressure and blood vessel function will be measured.

Timeline

Start: 2018-11-07
Primary completion: 2023-02-20
Completion: 2023-02-20

Publications

Delgado Spicuzza JM, Gosalia J, Zhong L, Bondonno C, Petersen KS, De Souza MJ, Alipour E, Kim-Shapiro DB, Somani YB, Proctor DN. Seven-day dietary nitrate supplementation clinically significantly improves basal macrovascular function in postmenopausal women: a randomized, placebo-controlled, double-blind, crossover clinical trial. Front Nutr. 2024 Jun 10;11:1359671. doi: 10.3389/fnut.2024.1359671. eCollection 2024.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Nitrate Rich Beetroot Juice	Unknown	140 ml	Oral

Indications

No indication recorded.