drugset / Trial / NCT03646357
BEtablocker Treatment After Acute Myocardial Infarction in Patients Without Reduced Left Ventricular Systolic Function
Phase 4
Active not recruiting
2895 enrolled
Oslo University Hospital
Diakonhjemmet Hospital · collabHaukeland University Hospital · collabHelse Stavanger HF · collabLovisenberg Diakonale Hospital · collabNordlandssykehuset HF · collabNorwegian University of Science and Technology · collabOstfold Hospital Trust · collabSorlandet Hospital HF · collabSt. Olavs Hospital · collabSykehuset Innlandet HF · collabThe Hospital of Vestfold · collabUniversity Hospital of North Norway · collabUniversity of Oslo · collabVestre Viken Hospital Trust · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The study aims to investigate whether oral betablocker (BB) therapy is superior to no such treatment following an acute myocardial infarction (AMI).
Timeline
- Start
- 2018-10-01
- Primary completion
- 2025-04-04
- Completion
- 2035-12-10
Publications
- Munkhaugen J, Kristensen AMD, Halvorsen S, Holmager T, Olsen MH, Bakken A, Sehested TSG, Ruddox V, Maeng M, Vikenes K, Jensen SE, Steigen T, Lambrechtsen J, Jortveit J, Bovin A, Schirmer H, Christiansen MK, Wiseth R, Mikkelsen D, Larsen AI, Lyngby Kjaergaard C, Andresen K, Gustafsson I, Tuseth V, Larsen ML, Deeg PS, Veien K, Bohmer E, Botker HE, Brattrud AO, Bronnum-Schou J, Pettersen AR, Bang LE, Oie E, Engstrom T, Borg EB, Kristensen K, Nymo SH, Gislason G, Vethe NT, Abdulla JAM, Dammen T, Mouridsen MR, Bendz B, Bertelsen MLN, Hove JD, Schierbeck L, Snoer M, Davidsen C, Egholm G, Thomsen KK, Jadou G, Poenaru M, Krarup NT, Bottcher M, Staehr PB, Zwisler AD, Edvardsen T, Torp-Pedersen C, Otterstad JE, Lange T, Fagerland MW, Atar D, Prescott E; BETAMI-DANBLOCK Investigators. Beta-Blockers after Myocardial Infarction in Patients without Heart Failure. N Engl J Med. 2025 Nov 13;393(19):1901-1911. doi: 10.1056/NEJMoa2505985. Epub 2025 Aug 30.
- Granger CB, Pocock SJ, Gersh BJ. The need for new clinical trials of old cardiovascular drugs. Nat Rev Cardiol. 2023 Feb;20(2):71-72. doi: 10.1038/s41569-022-00819-1. No abstract available.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Bisoprolol | Other / unclassified | 10 mg | — |
| Comparator | Carvedilol | Other / unclassified | 50 mg | — |
| Comparator | Metoprolol | Other / unclassified | 200 mg | — |