drugset / Trial / NCT03652974
Disturbance of Plasma Cytokine Parameters in Clozapine-Resistant Treatment-Refractory Schizophrenia (CTRS) and Their Association With Combination Therapy
Phase 4
Completed
145 enrolled
Shanghai Mental Health Center
Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University · collabThe Affiliated Brain Hospital of Guangzhou Medical University · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
In this study, investigators designed a double-blind randomized trial to compare the efficacy and safety between sodium valproate, amisulpride and MECT combination therapy in clozapine-treated refractory schizophrenia (CTRS).
Timeline
- Start
- 2018-09-06
- Primary completion
- 2021-08-30
- Completion
- 2021-08-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amisulpride | Small molecule | 800 mg | — |
| Subject | Valproate | Small molecule | 1000 mg | — |
| Background | Clozapine | Other / unclassified | 300 mg | — |
| Background | Clozapine | Other / unclassified | 600 mg | — |