Diluted Insulin in Young Children: Bigger Volumes for Smaller Patients

Summary

The aim of this study is to compare the pharmacokinetic (PK) profile of diluted insulin aspart (U25) with undiluted insulin aspart (U100) in school-aged children and adolescents with type 1 diabetes (T1D) utilizing the euglycemic clamp technique and a standardized meal in a controlled research environment. The investigators hypothesize that dilution of insulin aspart (U25) will alter the PK properties as compared to undiluted aspart.

Timeline

Start

2020-01-01

Primary completion

2023-06-30

Completion

2023-06-30

Drugs

Indications