drugset / Trial / NCT03666390

Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and Suicide

NCT03666390 ↗

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Depression and suicide are two leading mental health and public health issues in Taiwan. However, until now, the optimal treatment for refractory depression and suicide is still lacking. Previous USA studies suggested a low dose NMDA antagonist Ketamine infusion can significantly reduce depression and suicide. In our study, we firstly investigate the anti-suicide and anti-depressive effects of ketamine in Taiwan. If we can find the similar antidepressant and anti-suicide of ketamine in Taiwanese, this result will have a great influence in the current suicide and depression prevention programs.

Timeline

Start
2018-09-10
Primary completion
2021-12-31
Completion
2021-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Ketamine Small molecule 0.5 mg/kg —
Comparator Midazolam Small molecule 0.045 mg/kg —