Soluble Corn Fiber Supplementation for Asthma

Summary

Studies of the importance of the human microbiome have demonstrated that microbial metabolites of fermentation of our dietary products (e.g. dietary fiber) have a multitude of health benefits. The investigators aim to determine whether supplementation of asthmatic children with soluble corn fiber alongside standard of care reduces airway inflammation driven by the gut microbial metabolites acetate, propionate, or butyrate (short chain fatty acids).

Timeline

Start

2019-09-01

Primary completion

2021-12-31

Completion

2021-12-31

Publications

• Rank MA, Barroso DL, Conn KA, Pecak M, Scandura M, Hirsch AH, Gu H, Whisner CM, Shearer H, Johnson D, Argel N, Bauer CS, Williams SN, Wright BL, Woodward J, Cope EK. A randomized, double-blind, placebo-controlled trial of soluble corn fiber supplementation for children with asthma. Front Allergy. 2026 Jan 21;6:1707834. doi: 10.3389/falgy.2025.1707834. eCollection 2025.

Drugs

Indications