drugset / Trial / NCT03680508

TSR-022 (Anti-TIM-3 Antibody) and TSR-042 (Anti-PD-1 Antibody) in Patients With Liver Cancer

NCT03680508

Phase 2 Active not recruiting 42 enrolled University of Hawaii GlaxoSmithKline · collab
NaSingle-groupOpen-labelTreatment

Summary

TSR-022 (cobolimab, TIM-3 binding antibody) and TSR-042 (dostarlimab, PD-1 binding antibody) may stop the growth of tumor cells by allowing the immune system to attack the cancer. This phase II trial is studying how well TSR-022 (cobolimab, TIM-3 binding antibody) and TSR-042 (dostarlimab, PD-1 binding antibody) work in combination in treating patients with locally advanced or metastatic liver cancer.

Timeline

Start
2019-12-19
Primary completion
2026-03-06
Completion
2027-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Cobolimab Monoclonal antibody Intravenous
Subject Dostarlimab Monoclonal antibody Intravenous