The Impact of Imprinting and Repeated Influenza Vaccination on Adaptive Immunity, Transcriptomics, and Metabolomics

Phase 4 Terminated 39 enrolled Emory University

Non-randomizedParallel-groupOpen-labelBasic science

Summary

The goal of this study is to understand the impact on the human immune system's response to the four strain flu vaccine in individuals who have "imprinted" on specific influenza strains. It will also consider the effects of repeated prior annual influenza vaccination on the immune system.

Timeline

Start: 2018-10-22
Primary completion: 2020-06-20
Completion: 2020-06-20

Outcome

Outcome not reported

Stopped: “The study closed prior to completing year 3 of the study due to the COVID-19 pandemic.”

Publications

Results Sherman AC, Lai L, Bower M, Natrajan MS, Huerta C, Karmali V, Kleinhenz J, Xu Y, Rouphael N, Mulligan MJ. The Effects of Imprinting and Repeated Seasonal Influenza Vaccination on Adaptive Immunity after Influenza Vaccination. Vaccines (Basel). 2020 Nov 7;8(4):663. doi: 10.3390/vaccines8040663.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fluarix Quadrivalent	Vaccine	—	—