drugset / Trial / NCT03692819

Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis.

NCT03692819

Completed 45 enrolled São Paulo State University
RandomizedParallel-groupTriple-blindTreatment

Summary

Currently, with the increase of bacterial resistance to antibiotics associated with its side effects, it is necessary to find other adjuncts to combat the disease that are an alternative to the use of antibiotics. The use of probiotics has been proposed in the literature as an adjunct therapy for the treatment of periodontal diseases, however, few controlled and randomized clinical studies have been performed. The objective of this double-blind randomized controlled trial will be to evaluate the response of clinical and microbiological periodontal parameters to the comparison of two different adjuvant therapies (antibiotic and probiotic) for the treatment of stages II and III grade B periodontitis.

Timeline

Start
2018-05-02
Primary completion
2020-08-20
Completion
2020-09-20

Drugs

EvaluationDrugModalityDoseRoute
Subject Amoxicillin Other / unclassified 500 mg
Subject Lactobacillus reuteri Other / unclassified Oral
Subject Metronidazole Small molecule 400 mg

Indications