The Application of Zishen Yutai Pill in Aged Women Undergoing IVF-ET

Completed 1467 enrolled Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

RandomizedParallel-groupDouble-blindTreatment

Summary

To explore the application of Zishen Yutai Pill in controlled ovarian stimulation and effect on pregnancy outcome in aged women undergoing in vitro fertilization-embryo transfer.

Timeline

Start: 2019-03-04
Primary completion: 2024-09-14
Completion: 2024-09-14

Outcome

Met primary endpoint

registry Zishen Yutai Pill Group vs Placebo Group; p = 0.042; Risk Ratio (RR) 1.23 (95% CI 1.01 to 1.50) NCT03703700 ↗

paper live birth occurred in 23.3% (171/734) with ZYP vs. 19.0% (139/733) with placebo PMID 41444477 ↗

Publications

Li Y, Gong F, Wang X, Hu L, Li H, Guan Y, Ye H, Fan L, Bai H, Wang Z, Huang W, Ma X, Yang D, Zhang H. Zishen Yutai Pill increased live births in advanced maternal age women: a randomized clinical trial. Nat Commun. 2025 Dec 24;17(1):980. doi: 10.1038/s41467-025-67714-4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Zishen Yutai Pill	Unknown	5 g	Oral