Genetic Polymorphisms of ABCG2/BCRP on the Transport of Nifedipine to Breast Milk.

Phase 4 Unknown 19 enrolled Natalia Valadares de Moraes Hospital das Clínicas de Ribeirão Preto · collab

Non-randomizedParallel-groupOpen-labelTreatment

Summary

This study aims to investigate the influence of the c.421C\>A genetic polymorphism of the ABCG2 / BCRP transporter in the concentration ratio of nifedipine in maternal milk:plasma in hypertensive breastfeeding women attended at the Gynecology and Obstetrics Service of the Medical School of Ribeirão Preto, of the University of São Paulo. Thus, plasma and breast milk samples are being collected from patients in chronic use of the drug (n=30) within 15 to 30 days postnatal.

Timeline

Start: 2015-12-14
Primary completion: 2018-02-01
Completion: 2019-10-01

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nifedipine	Other / unclassified	20 mg	—

Indications

No indication recorded.