Carbetocin on Myocardial Repolarization Dynamics in Obstetrics Study

Summary

Relationship between carbetocin dose on transmural dispersion of repolarization (TDR).

Timeline

Start

2018-11-01

Primary completion

2019-06-15

Completion

2020-04-24

Outcome

Met primary endpoint

paper Tp-e in C100 was 4.1 milliseconds longer compared to C50 (95% confidence interval [CI], 0.8-7.5; P = .01). PMID 32149759 ↗

paper Tp-e was unaffected by C50 IV given after CD in healthy parturients under spinal anesthesia, but minimally prolonged by C100. PMID 32149759 ↗

Publications

• Clunies-Ross N, Roston TM, Taylor J, Whyte S, Albert A, Gorges M, Chau A. The Effect of Carbetocin Dose on Transmural Dispersion of Myocardial Repolarization in Healthy Parturients Scheduled for Elective Cesarean Delivery Under Spinal Anesthesia: A Prospective, Randomized Clinical Trial. Anesth Analg. 2021 Feb 1;132(2):485-492. doi: 10.1213/ANE.0000000000004712.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Carbetocin	Peptide	50 ug	Intravenous
Subject	Carbetocin	Peptide	100 ug	Intravenous

Indications