Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients

Completed 58 enrolled Stuart Mazzone Imperial College London · collab Monash University · collab Queen's University, Belfast · collab

Non-randomizedParallel-groupOpen-labelBasic science

Summary

Persistent cough is a distressing symptom for people with respiratory disorders. Patients also often experience an ongoing urge-to-cough that prompts coughing, and which fails to resolve the sensation. Understanding how the brain controls cough and the urge-to-cough could lead to new cough suppressing therapies. The overall objective of this project is to use functional brain imaging (fMRI) to identify brain regions that are involved in the exaggerated urge-to-cough in humans with chronic cough. Our focus will be on the brainstem where information from the airways first arrives in the central nervous system.

Timeline

Start: 2019-03-01
Primary completion: 2022-05-13
Completion: 2022-05-13

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Capsaicin	Small molecule	0.0005 mmol	Inhaled
Subject	Capsaicin	Small molecule	0.125 mmol	Inhaled
Subject	adenosine triphosphate	Small molecule	0.2 mmol	Inhaled
Subject	adenosine triphosphate	Small molecule	300 mmol	Inhaled

Indications

No indication recorded.