Carvedilol for Prevention of Esophageal Varices Progression

Summary

Carvedilol has been shown to be more potent in decreasing portal hypertension to propranolol. But the efficacy of carvedilol to delay the growth of esophageal varices in chronic hepatitis B patients was unclear.

Timeline

Start

2017-10-09

Primary completion

2022-11-30

Completion

2022-12-30

Outcome

Missed primary endpoint

paper relative risk = 0.79, 95% confidence interval 0.36-1.75, P = 0.567 PMID 37929952 ↗

Publications

• Wang B, Zhou J, Wu X, Sun Y, Li L, Li P, Li M, Jiang W, Xu M, Feng B, Xu X, Cheng J, Xie W, Han T, Wang X, Li H, Piao H, Zhao X, Chen S, Meng T, Guan Q, Meng F, Kong Y, Ou X, Jia J, You H. Carvedilol Plus NUC for Patients With HBV-Compensated Cirrhosis Under Virological Suppression: A Randomized Open-Label Trial. Am J Gastroenterol. 2024 Apr 1;119(4):700-711. doi: 10.14309/ajg.0000000000002569. Epub 2023 Nov 6.

Drugs

Indications