drugset / Trial / NCT03737708
A Study Comparing Biologics + Methotrexate With Biologics + Tacrolimus in Patients With Rheumatoid Arthritis (RA)
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to compare the efficacy of Biologics + Methotrexate with Biologics + Tacrolimus measured by the disease activity score 28 (DAS28) erythrocyte sedimentation rate (ESR) and the American College of Rheumatology (ACR) scores. The study will also assess the safety of the combinations.
Timeline
- Start
- 2019-02-13
- Primary completion
- 2020-06-16
- Completion
- 2020-06-16
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Methotrexate | Small molecule | — | Oral |
| Subject | Tacrolimus | Small molecule | — | Oral |
| Background | Abatacept | Other / unclassified | — | Intravenous |
| Background | Adalimumab | Monoclonal antibody | — | Subcutaneous |
| Background | Tocilizumab | Monoclonal antibody | — | Intravenous |