drugset
drugset / Trial / NCT03738943

Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults

NCT03738943 ↗

Phase 0 Completed 9 enrolled Colorado State University
RandomizedParallel-groupOpen-labelBasic science

Summary

Previous research has identified adenosine triphosphate (ATP) as an important vasodilator that is released from red blood cells during exercise and exposure to hypoxic environments in adult humans. Further, older adults appear to have lower blood flow during both of these stressors and also have lower amounts of ATP released from their red blood cells. However, the contribution of ATP to vasodilation in response to exercise and hypoxia is currently unknown due to the lack of an effective ATP receptor antagonist. We aim to determine whether Vitamin B6 or its metabolite, Pyridoxal-5-Phosphate (PLP) is an effective ATP receptor antagonist.

Timeline

Start
2019-02-07
Primary completion
2021-06-01
Completion
2021-06-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Acetylcholine Small molecule 1 unknown Other
Subject Acetylcholine Small molecule 4 unknown Other
Subject Acetylcholine Small molecule 8 unknown Other
Subject Acetylcholine Small molecule 16 unknown Other
Subject Adenosine Small molecule 3.125 unknown Other
Subject Adenosine Small molecule 6.25 unknown Other
Subject Adenosine Small molecule 12.5 unknown Other
Subject Adenosine Small molecule 25 unknown Other
Subject Adenosine Diphosphate Small molecule 20 unknown Other
Subject Adenosine Diphosphate Small molecule 40 unknown Other
Subject Adenosine Diphosphate Small molecule 80 unknown Other
Subject Adenosine Diphosphate Small molecule 160 unknown Other
Subject Adenosine Monophosphate Unknown 25 unknown Other
Subject Adenosine Monophosphate Unknown 50 unknown Other
Subject Adenosine Monophosphate Unknown 100 unknown Other
Subject Adenosine Monophosphate Unknown 200 unknown Other
Subject Pyridoxal 5'-Phosphate Unknown 200 unknown Other
Subject Pyridoxine Unknown 2.5 mg Other
Subject Sodium Nitroprusside Unknown 0.25 unknown Other
Subject Sodium Nitroprusside Unknown 0.5 unknown Other
Subject Sodium Nitroprusside Unknown 1 unknown Other
Subject Sodium Nitroprusside Unknown 2 unknown Other
Subject Uridine Triphosphate Unknown 1.25 unknown Other
Subject Uridine Triphosphate Unknown 2.5 unknown Other
Subject Uridine Triphosphate Unknown 5 unknown Other
Subject Uridine Triphosphate Unknown 10 unknown Other
Subject adenosine triphosphate Small molecule 1.25 unknown Other
Subject adenosine triphosphate Small molecule 2.5 unknown Other
Subject adenosine triphosphate Small molecule 5 unknown Other
Subject adenosine triphosphate Small molecule 10 unknown Other

Indications

No indication recorded.