Apremilast and Moderate to Severe Chronic Hand Dermatitis

Summary

Investigators have designed a pilot study involving chronic hand dermatitis (CHD) patients who attend the dermatology clinic at the George Washington Medical Faculty Associates (GW MFA) in order to assess the efficacy and safety of apremilast treatment for the treatment of moderate to severe CHD.

Timeline

Start

2019-02-28

Primary completion

2019-08-01

Completion

2019-08-01

Outcome

Outcome not reported

Stopped: “The principal investigator left George Washington University and closed the study at their departure.”

Publications

• Background Coenraads PJ. Hand eczema. N Engl J Med. 2012 Nov 8;367(19):1829-37. doi: 10.1056/NEJMcp1104084.
• Background Menne T, Johansen JD, Sommerlund M, Veien NK; Danish Contact Dermatitis Group. Hand eczema guidelines based on the Danish guidelines for the diagnosis and treatment of hand eczema. Contact Dermatitis. 2011 Jul;65(1):3-12. doi: 10.1111/j.1600-0536.2011.01915.x.
• Background English J, Aldridge R, Gawkrodger DJ, Kownacki S, Statham B, White JM, Williams J. Consensus statement on the management of chronic hand eczema. Clin Exp Dermatol. 2009 Oct;34(7):761-9. doi: 10.1111/j.1365-2230.2009.03649.x.
• Background Berg S. Prävalenz von Handekzemen in Heidelberg und weltweit - die Heidelberger Prävalenzstudie im Vergleich mit Ergebnissen aus der Literatur. Dissertation, Heidelberg, 2005
• Background Hald M, Berg ND, Elberling J, Johansen JD. Medical consultations in relation to severity of hand eczema in the general population. Br J Dermatol. 2008 Apr;158(4):773-7. doi: 10.1111/j.1365-2133.2007.08431.x. Epub 2008 Jan 30.
• Background Brunner PM, Leung DYM, Guttman-Yassky E. Immunologic, microbial, and epithelial interactions in atopic dermatitis. Ann Allergy Asthma Immunol. 2018 Jan;120(1):34-41. doi: 10.1016/j.anai.2017.09.055. Epub 2017 Nov 7.
• Background Bissonnette R, Haydey R, Rosoph LA, Lynde CW, Bukhalo M, Fowler JF, Delorme I, Gagne-Henley A, Gooderham M, Poulin Y, Barber K, Jenkin P, Landells I, Pariser DM. Apremilast for the treatment of moderate-to-severe palmoplantar psoriasis: results from a double-blind, placebo-controlled, randomized study. J Eur Acad Dermatol Venereol. 2018 Mar;32(3):403-410. doi: 10.1111/jdv.14647. Epub 2017 Nov 15.

Drugs

Indications