drugset / Trial / NCT03743103

Esmolol for the Treatment of Hypertension After Intracerebral Hemorrhage Study (ETHICHS)

NCT03743103

RandomizedParallel-groupOpen-labelTreatment

Summary

Because of its pharmacokinetic characteristics, such as short half-life and its safety profile, esmolol hydrochloride is a beta blocker suitable for venous use in the form of continuous infusion. Strategies that improve the blood pressure control of patients with hemorrhagic stroke during the first hours of hospitalization are determinant in controlling the hematoma expansion and determining factor in its prognosis. This study was designed with the objective of evaluating the beneficial effects of combining esmolol hydrochloride with sodium nitroprusside for the blood pressure control of participants with hemorrhagic stroke.

Timeline

Start
2019-04-18
Primary completion
2021-10-31
Completion
2021-10-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Esmolol Other / unclassified 10 ml Intravenous
Background Sodium Nitroprusside Unknown 0.5 ug/kg