drugset / Trial / NCT03744767

Adjuvant Anti-Mineralocorticoid-Receptor Treatment in Anti-VEGF Refractory Neovascular Age-Related Macular Degeneration

NCT03744767

Phase 2 Completed 20 enrolled Dr Irmela MANTEL
SequentialOpen-labelTreatment

Summary

Prospective, non-comparative, mono-center pilot study. Patients with neovascular age-related macular degeneration (nAMD), responding insufficiently to the maximal standard care with monthly intravitreal anti-VEGF injections are given adjuvant oral mineralocorticoid receptor antagonists for 4 months and observed for any changes in vision or retinal structure during the 4 months of adjuvant treatment, plus 2 additional months without adjuvant treatment.

Timeline

Start
2014-09-19
Primary completion
2015-09-22
Completion
2015-09-22

Drugs

EvaluationDrugModalityDoseRoute
Subject Spironolactone Small molecule 50 mg Oral