drugset / Trial / NCT03759288

An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Crohn's Disease

NCT03759288

Phase 2/3 Terminated 89 enrolled AstraZeneca
RandomizedParallel-groupTriple-blindTreatment

Summary

This study seeks to evaluate the safety and efficacy of brazikumab versus placebo (Stage I) and versus an active comparator (Stage 2) in participants with moderately to severely active CD and will include assessments of clinical response as demonstrated by improvement of symptoms and colonic mucosal appearance as observed on endoscopy

Timeline

Start
2018-12-07
Primary completion
2023-10-18
Completion
2023-10-18

Drugs

EvaluationDrugModalityDoseRoute
Comparator Adalimumab Monoclonal antibody Subcutaneous
Subject Brazikumab Unknown Intravenous

Indications