drugset / Trial / NCT03760718
Chloroprocaine Lavage to Improve Outcomes Related to Operative Cesarean Delivery
Non-randomizedParallel-groupOpen-labelTreatment
Summary
The long term objective is to show that intraperitoneal chloroprocaine can be used an alternative option to avoid general anesthesia during cesarean delivery, to alleviate mother's discomfort from surgical pain, reduce complications, and improve the birth experience. The objectives in this study are to determine the amount of chloroprocaine that is absorbed into the blood in order to create a plasma concentration time profile and to determine the incidence of side effects to help guide selection of an appropriate concentration for future study.
Timeline
- Start
- 2019-09-30
- Primary completion
- 2020-09-17
- Completion
- 2021-12-31
Publications
- Background Ranney B, Stanage WF. Advantages of local anesthesia for cesarean section. Obstet Gynecol. 1975 Feb;45(2):163-7.
- Togioka BM, Zarnegarnia Y, Bleyle LA, Koop D, Brookfield K, Yanez ND, Treggiari MM. Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery. Anesth Analg. 2022 Oct 1;135(4):777-786. doi: 10.1213/ANE.0000000000006064. Epub 2022 May 11.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Chloroprocaine | Other / unclassified | 1 % | Other |
| Comparator | Chloroprocaine | Other / unclassified | 2 % | Other |
| Comparator | Chloroprocaine | Other / unclassified | 3 % | Other |
Indications
No indication recorded.