drugset / Trial / NCT03768219
Study to Evaluate APVO210 in Healthy Subjects, Patients With Psoriasis, and Patients With Ulcerative Colitis
RandomizedSequentialQuadruple-blindTreatment
Summary
Phase 1 study in 2 stages with 2 expansion cohorts. The first stage is a single ascending dose (SAD) study of APVO210 in healthy volunteers. The second stage is a multiple ascending dose (MAD) study of APVO210 in healthy volunteers. Two expansion cohorts evaluate multiple doses of APVO210 in psoriasis patients and ulcerative colitis patients.
Timeline
- Start
- 2019-03-18
- Primary completion
- 2020-06-30
- Completion
- 2020-06-30
Outcome
Outcome not reported
Stopped (Business): “Business decision”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | APVO210 | Unknown | 2 ug/kg | — |
| Subject | APVO210 | Unknown | 5 ug/kg | — |
| Subject | APVO210 | Unknown | 10 ug/kg | — |
| Subject | APVO210 | Unknown | 20 ug/kg | — |
| Subject | APVO210 | Unknown | 40 ug/kg | — |
| Subject | APVO210 | Unknown | 80 ug/kg | — |
| Subject | APVO210 | Unknown | 160 ug/kg | — |
| Subject | APVO210 | Unknown | 320 ug/kg | — |
| Subject | APVO210 | Unknown | 360 ug/kg | — |