Comparison of BIS Index Variations: Bolus Versus Infusion Ketamine, and Impact on the Anesthesia Gas Consumption

Phase 4 Completed 50 enrolled Ciusss de L'Est de l'Île de Montréal

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The aim of the present study is to show that i.v. ketamine boluses might lead to significant and clinically relevant BIS index increase that might lead to an increase in anesthesia dosing (halogenous gas) when compared to an i.v. continuous infusion of ketamine without any bolus.

Timeline

Start: 2018-09-25
Primary completion: 2019-03-29
Completion: 2019-09-30

Publications

Carrara L, Nault M, Morisson L, Godin N, Idrissi M, Fortier A, Guertin MC, Brulotte V, Fortier LP, Verdonck O, Richebe P. The impact of bolus versus continuous infusion of intravenous ketamine on bispectral index variations and desflurane administration during major surgery: The KETABIS study. Eur J Anaesthesiol. 2021 Nov 1;38(11):1168-1179. doi: 10.1097/EJA.0000000000001588.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Ketamine	Small molecule	0.25 mg/kg	Intravenous

Indications

No indication recorded.