Systematic Evaluation of Protamine Doze in Cardiac Surgery

Unknown 100 enrolled London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

NaSingle-groupOpen-labelTreatment

Summary

The precise amount of protamine required to neutralize unfractionated heparin (UFH) remains unknown. This study will systematically identify the doze needed to neutralize UFH following cardiopulmonary bypass (CPB).

Timeline

Start: 2018-09-20
Primary completion: 2019-12-31
Completion: 2020-02-28

Publications

Taneja R, Szoke DJ, Hynes Z, Jones PM. Minimum protamine dose required to neutralize heparin in cardiac surgery: a single-centre, prospective, observational cohort study. Can J Anaesth. 2023 Feb;70(2):219-227. doi: 10.1007/s12630-022-02364-4. Epub 2022 Dec 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Protamine Sulfate	Unknown	300 mg	—

Indications

No indication recorded.