drugset / Trial / NCT03789006
Antithymocyte Globulin and Azathioprine Versus Basiliximab and Mycophenolate Mofetil in Living Donor Kidney Transplantation
Phase 4
Unknown
300 enrolled
University of Khartoum
National Center for Kidney Diseases and Surgery · collab
RandomizedParallel-groupOpen-labelPrevention
Summary
Kidney transplantation is the best available treatment option for patients with end stage renal disease. However, kidney transplantation requires life-long use of immunosuppressive medication. Because of the high cost of these medications we need to carefully evaluate the cost-effectiveness of each drug regimen, especially in low-middle income countries. The objective of this clinical trial is to compare the efficiency and cost of two immunosuppressive protocols after living donor kidney transplantation: (1) antithymocyte globulin, tacrolimus, azathioprine and prednisolone versus (2) basiliximab, tacrolimus, mycophenolate mofetil and prednisolone.
Timeline
- Start
- 2018-03-21
- Primary completion
- 2022-03-21
- Completion
- 2024-03-21
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Basiliximab | Monoclonal antibody | — | — |
| Comparator | Thymoglobulin | Protein / enzyme biologic | — | — |