drugset / Trial / NCT03790358
Mood Effects of Serotonin Agonists
RandomizedCrossoverTriple-blindBasic science
Summary
The purpose of this study is to determine the effects of very low doses of serotonergic agonists on depressed mood in human volunteers.
Timeline
- Start
- 2018-05-01
- Primary completion
- 2023-01-27
- Completion
- 2023-01-27
Publications
- Bershad AK, Preller KH, Lee R, Keedy S, Wren-Jarvis J, Bremmer MP, de Wit H. Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Apr;5(4):461-467. doi: 10.1016/j.bpsc.2019.12.007. Epub 2019 Dec 20.
- Bershad AK, Schepers ST, Bremmer MP, Lee R, de Wit H. Acute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers. Biol Psychiatry. 2019 Nov 15;86(10):792-800. doi: 10.1016/j.biopsych.2019.05.019. Epub 2019 Jun 3.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lysergic Acid Diethylamide | Other / unclassified | 6.5 ug | — |
| Subject | Lysergic Acid Diethylamide | Other / unclassified | 13 ug | — |
| Subject | Lysergic Acid Diethylamide | Other / unclassified | 26 ug | — |
Indications
No indication recorded.