Psoriatic Oligoarthritis Intervention With Symptomatic thErapy

Phase 4 Completed 1 enrolled University of Oxford National Institute for Health Research, United Kingdom · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

POISE is a two arm interventional trial nested within a cohort (Trials Within Cohorts or TWiCs design). This tests less aggressive early therapy in patients newly diagnosed with low impact oligoarticular PsA. Arm 1 will receive standard step up therapy in the cohort and act as the control group. Arm 2 will receive local steroid injections to active joints and will be able to use non-steroidal anti-inflammatory drugs (NSAIDs) only

Timeline

Start: 2019-04-17
Primary completion: 2020-07-16
Completion: 2020-07-16

Publications

Rombach I, Tucker L, Tillett W, Jadon D, Watson M, Francis A, Sinomati Y, Dutton SJ, Coates LC. Clinical effectiveness of symptomatic therapy compared with standard step-up care for the treatment of low-impact psoriatic oligoarthritis: the two-arm parallel group randomised POISE feasibility study. Ther Adv Musculoskelet Dis. 2022 Jan 10;13:1759720X211057668. doi: 10.1177/1759720X211057668. eCollection 2021.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Leflunomide	Small molecule	10 mg	Oral
Comparator	Leflunomide	Small molecule	20 mg	Oral
Comparator	Methotrexate	Small molecule	25 mg	Oral
Subject	Methylprednisolone	Other / unclassified	20 mg	Other
Subject	Methylprednisolone	Other / unclassified	120 mg	Other
Comparator	Sulfasalazine	Small molecule	3 g	Oral
Subject	Triamcinolone	Other / unclassified	20 mg	Other
Subject	Triamcinolone	Other / unclassified	120 mg	Other

Psoriatic Oligoarthritis Intervention With Symptomatic thErapy

Summary

Timeline

Publications

Drugs

Indications