drugset / Trial / NCT03799562

Neurosteroids for PTSD in Veterans

NCT03799562

Phase 2 Completed 96 enrolled VA Office of Research and Development
RandomizedParallel-groupQuadruple-blindTreatment

Summary

This study seeks to determine if pregnenolone can improve symptoms of PTSD and other symptoms that commonly occur with PTSD in Iraq/Afghanistan-era Veterans. The total study duration is 10 weeks. Eligible Veterans with PTSD will receive either pregnenolone or placebo throughout the study duration and will complete mental and physical health assessments at each study visit. Eligible participants will attend 6 in-person study visits and receive several short "check-in" phone calls.

Timeline

Start
2019-05-01
Primary completion
2025-07-07
Completion
2025-07-14

Drugs

EvaluationDrugModalityDoseRoute
Subject Pregnenolone Other / unclassified 250 mg