drugset / Trial / NCT03802721
Pharmacokinetics of Benzo[a]Pyrene: Impact of Diet
Phase 0
Completed
7 enrolled
Oregon State University
Lawrence Livermore National Laboratory · collabNational Institute of Environmental Health Sciences (NIEHS) · collabPacific Northwest National Laboratory · collab
NaSingle-groupOpen-labelBasic science
Summary
Evaluation of the pharmacokinetics for \[14C\]-benzo\[a\]pyrene (\[14C\]-BaP) and metabolites in plasma and urine over 48 hours following a 50 ng dose (5.4 nCi) alone, following 7 days' consumption of Brussels sprouts, and following 7 days' consumption of a supplement containing 3,3'-diindolylmethane (DIM).
Timeline
- Start
- 2019-01-24
- Primary completion
- 2024-01-01
- Completion
- 2024-02-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | ARUNDINE | Small molecule | 300 mg | Oral |
| Subject | [14C]-benzo[a]pyrene | Unknown | 50 ng | Oral |