drugset / Trial / NCT03806985
Effects of Psilocybin in Concussion Headache
RandomizedCrossoverDouble-blindTreatment
Summary
The purpose of this study is to investigate the effects of oral psilocybin in post-traumatic headache. Subjects will be randomized to receive placebo, low dose psilocybin, or high dose psilocybin on two separate test days approximately 14 days apart. Subjects will maintain a headache diary prior to, during, and after the treatments in order to document headache frequency and intensity, as well as associated symptoms. Blood samples will be drawn at various timepoints to measure levels of inflammatory peptides.
Timeline
- Start
- 2019-03-28
- Primary completion
- 2023-06-27
- Completion
- 2023-06-27
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Psilocybin | Other / unclassified | 0.0143 mg/kg | Oral |
| Subject | Psilocybin | Other / unclassified | 0.143 mg/kg | Oral |
| Subject | Psilocybin | Other / unclassified | 1 mg | Oral |
| Subject | Psilocybin | Other / unclassified | 10 mg | Oral |