Effects of Nitroglycerin Versus Labetalol on Tissue Perfusion During Deliberate Hypotension

Summary

Deliberate hypotension is used to provide bloodless field during endoscopic sinus surgery; however, hypotension might impair perfusion of vital organs. The aim of this work is to compare the impact of nitroglycerin and labetalol on peripheral perfusion when used for induction of deliberate hypotension

Timeline

Start

2019-01-19

Primary completion

2019-05-25

Completion

2019-05-25

Outcome

Met primary endpoint

paper The nitroglycerin group exhibited a higher peripheral perfusion index at nearly all records (p < 0.0001) PMID 32303182 ↗

Publications

• Zayed M, Nassar H, Hasanin A, Saleh AH, Hassan P, Saad D, Mahmoud S, Abo Bakr G, Fouad E, Saleh N, Ismail M, El-Hadi H. Effects of nitroglycerin versus labetalol on peripheral perfusion during deliberate hypotension for sinus endoscopic surgery: a randomized, controlled, double-blinded trial. BMC Anesthesiol. 2020 Apr 17;20(1):85. doi: 10.1186/s12871-020-01006-w.

Drugs

Indications