A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

Summary

This study will look at the long-term effects of semaglutide (active medicine) on diabetic eye disease when compared to placebo (dummy medicine). The study will be performed in people with type 2 diabetes. Participants will either get semaglutide or placebo in addition to their diabetes medicines - which treatment the participant gets is decided by chance. Participants will inject the study medicine using a pen-injector. The medicine must be injected in a skin fold in the stomach, thigh or upper arm once a week. The study will last for 5 years.

Timeline

Start

2019-05-08

Primary completion

2027-11-07

Completion

2027-11-07

Publications

• Ntentakis DP, Correa VSMC, Ntentaki AM, Vavvas DG. Differences in effects of some newer-generation anti-diabetics on diabetic retinopathy versus nephropathy. Graefes Arch Clin Exp Ophthalmol. 2024 Apr;262(4):1371-1372. doi: 10.1007/s00417-023-06353-1. Epub 2024 Jan 10. No abstract available.

Drugs

Indications