The Effects of Sedatives on Tobacco Use Disorder

Phase 1/2 Completed 10 enrolled Wake Forest University Health Sciences

RandomizedParallel-groupSingle-blindBasic science

Summary

This proposal will obtain preliminary data on the effect of a single sub-anesthetic dose of a sedative on cigarette craving and smoking behavior as well as measuring tolerability and acceptability.

Timeline

Start: 2019-06-01
Primary completion: 2021-08-31
Completion: 2021-08-31

Publications

Chuang J, Lide RC, Kamath N, Oliveto A, Addicott M. A pilot study of ketamine among individuals with tobacco use disorder: tolerability and initial impact on tobacco use outcomes. J Addict Dis. 2026 Jan-Mar;44(1):83-87. doi: 10.1080/10550887.2025.2450129. Epub 2025 Jan 20.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	0.5 mg/kg	Intravenous
Subject	Midazolam	Small molecule	0.02 mg/kg	Intravenous

The Effects of Sedatives on Tobacco Use Disorder

Summary

Timeline

Publications

Drugs

Indications