drugset / Trial / NCT03818776

Proton Based Cardiac Sparing Accelerated Fractionated RadioTherapy in Unresectable NSCLC

NCT03818776

Phase 0 Terminated 7 enrolled Case Comprehensive Cancer Center
Non-randomizedSequentialOpen-labelTreatment

Summary

The purpose of this study is to treat participants with the combination of durvalumab (the study drug) and proton beam therapy. Proton beam therapy is a type of radiotherapy (RT) with a unique characteristic where the proton stops at a specific depth according to its energy. This may be advantageous in treating lung cancer because it allows for a sufficient tumor dose that may improve local control and survival while sparing normal organs at risk, such as the heart, lung, and spinal cord.

Timeline

Start
2019-08-30
Primary completion
2022-01-27
Completion
2022-01-27

Drugs

EvaluationDrugModalityDoseRoute
Subject Durvalumab Monoclonal antibody 20 mg/kg Intravenous
Subject Durvalumab Monoclonal antibody 1500 mg Intravenous