drugset / Trial / NCT03824327

Papaverine and Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer (NSCLC) or Lung Metastases

NCT03824327

Phase 1 Active not recruiting 19 enrolled Ohio State University Comprehensive Cancer Center
NaSingle-groupOpen-labelTreatment

Summary

This phase I trial studies the side effects and how well papaverine hydrochloride and stereotactic radiation therapy body (SBRT) work in treating patients with non-small cell lung cancer. Papaverine hydrochloride may help radiation therapy work better by making tumor cells more sensitive to the radiation therapy. Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method can kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Giving papaverine hydrochloride with SBRT may work in treating patients with non-small cell lung cancer.

Timeline

Start
2019-02-07
Primary completion
2026-08-31
Completion
2027-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Papaverine Small molecule Intravenous