Clemastine in Cardiovascular Surgery

Completed 100 enrolled Chinese Academy of Medical Sciences, Fuwai Hospital

RandomizedParallel-groupTriple-blindPrevention

Summary

In this study, a prospective, randomized, double-blind pilot trial designed to evaluate the effect of histamine H1 receptor antagonist clemastine on perioperative anaphylaxis in cardiovascular surgery with cardiopulmonary bypass, especially for the efficacy and safety on reducing heparin and protamine associated anaphylaxis.

Timeline

Start: 2019-02-20
Primary completion: 2019-07-31
Completion: 2020-01-10

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Clemastine	Small molecule	2 mg	Intramuscular

Indications

No indication recorded.