drugset / Trial / NCT03828773

PTX3-targeted Antifungal Prophylaxis

NCT03828773

RandomizedParallel-groupQuadruple-blindPrevention

Summary

This is a prospective genetically-stratified randomized double-blind event-driven multicentre clinical trial to assess the efficacy of posaconazole-based antifungal prophylaxis allocation strategies for patients with acute myeloid leukemia who receive induction chemotherapy. Allocation strategy based on an invasive mold infection genetic risk will be double-blinded.

Timeline

Start
2019-02-11
Primary completion
2027-11-30
Completion
2027-11-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Fluconazole Small molecule 200 mg Oral
Subject Fluconazole Small molecule 400 mg Oral
Subject Posaconazole Small molecule 300 mg Oral