drugset / Trial / NCT03828773
PTX3-targeted Antifungal Prophylaxis
RandomizedParallel-groupQuadruple-blindPrevention
Summary
This is a prospective genetically-stratified randomized double-blind event-driven multicentre clinical trial to assess the efficacy of posaconazole-based antifungal prophylaxis allocation strategies for patients with acute myeloid leukemia who receive induction chemotherapy. Allocation strategy based on an invasive mold infection genetic risk will be double-blinded.
Timeline
- Start
- 2019-02-11
- Primary completion
- 2027-11-30
- Completion
- 2027-11-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Fluconazole | Small molecule | 200 mg | Oral |
| Subject | Fluconazole | Small molecule | 400 mg | Oral |
| Subject | Posaconazole | Small molecule | 300 mg | Oral |