drugset / Trial / NCT03837925
Pharmaco-metabolomic Effects of Statins: METASTATINE
Phase 3
Completed
120 enrolled
French Cardiology Society
Fondation Coeur et Recherche · collabFédération Française de Cardiologie · collabICAN Nutrition Education and Research · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Statins are effective in cardio-vascular prevention by lowering LDL-Cholesterol levels but also through other mechanisms poorly understood. Our hypothesis is that some of these effects are mediated by microbiota alteration, leading to diminution of expression of microbiota derived pro-atherogenic metabolites.
Timeline
- Start
- 2019-06-13
- Primary completion
- 2022-12-21
- Completion
- 2022-12-21
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atorvastatin | Small molecule | 40 mg | — |