Use of Erythropoietin to Expand Regulatory T Cells in Autoimmune Liver Disease

Phase 0 Completed 6 enrolled Northwestern University Icahn School of Medicine at Mount Sinai · collab Mount Sinai Hospital, New York · collab

NaSingle-groupOpen-labelBasic science

Summary

This study evaluates the effect of erythropoietin on the number and function of regulatory T cells in adults with autoimmune hepatitis. Participants will receive a single dose of erythropoietin, and then the investigators will collect blood at different time points for analysis of regulatory T cell number and function.

Timeline

Start: 2019-01-25
Primary completion: 2021-02-18
Completion: 2021-02-18

Publications

McEachern E, Carroll AM, Fribourg M, Schiano TD, Hartzell S, Bin S, Cravedi P, Levitsky J. Erythropoietin administration expands regulatory T cells in patients with autoimmune hepatitis. J Autoimmun. 2021 May;119:102629. doi: 10.1016/j.jaut.2021.102629. Epub 2021 Mar 13.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	epoetin alfa	Protein / enzyme biologic	10000 iu	Subcutaneous

Use of Erythropoietin to Expand Regulatory T Cells in Autoimmune Liver Disease

Summary

Timeline

Publications

Drugs

Indications