drugset / Trial / NCT03843359

A First Time in Human (FTIH) Study of GSK3745417 Administered to Participants With Advanced Solid Tumors

NCT03843359

Phase 1 Active not recruiting 97 enrolled GlaxoSmithKline
Non-randomizedSequentialOpen-labelTreatment

Summary

This study aims to evaluate the safety, tolerability, and preliminary clinical activity and establish a recommended dose of GSK3745417 administered alone (Part 1A) or co-administered (Part 2A) with dostarlimab in participants with refractory/relapsed solid tumors. Both parts will consist of a dose escalation phase.

Timeline

Start
2019-03-12
Primary completion
2024-04-04
Completion
2026-03-31

Drugs

EvaluationDrugModalityDoseRoute
Subject GSK3745417 Unknown
Background Dostarlimab Monoclonal antibody

Indications