Copeptin After an Oral Stimulation With Macimorelin in Healthy Volunteers

Completed 28 enrolled University Hospital, Basel, Switzerland

SequentialOpen-labelDiagnostic

Summary

This study investigates stimulation of the posterior pituitary gland by oral Macimorelin (a ghrelin receptor Agonist) to be a novel diagnostic test in the polyuria-polydipsia syndrome.

Timeline

Start: 2019-03-07
Primary completion: 2019-07-16
Completion: 2019-07-16

Publications

Urwyler SA, Lustenberger S, Drummond JR, Soares BS, Vogt DR, Ammer N, Yuen KCJ, Ribeiro-Oliveira A, Christ-Crain M. Effects of oral macimorelin on copeptin and anterior pituitary hormones in healthy volunteers. Pituitary. 2021 Aug;24(4):555-563. doi: 10.1007/s11102-021-01132-9. Epub 2021 Feb 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Macimorelin	Small molecule	0.5 mg/kg	Oral
Subject	Macimorelin	Small molecule	0.75 mg/kg	Oral

Indications

No indication recorded.