Prophylatic Effect Preoperative Antibiotics With Mechanical Bowel Preparation in SSIs
Summary
Surgical site infection (SSI) is a major postoperative complication after abdominal surgery especially in colorectal field, which significantly increases length of stay (LOS), readmission incidence and expense. Therefore, identification of the effective method to reduce SSI incidence is critically important. Combination of oral antibiotics and mechanical bowel preparation was reported with lower SSIs and LOS in some retrospecitve data analysis, however a prospective randmized controlled trial was absent. Herein, the current randomized controlled trial comparing MBP+OA with MBP alone in postoperative complications in order to guide clinical practise was conducted.
Timeline
- Start
- 2019-01-17
- Primary completion
- 2022-12-30
- Completion
- 2023-03-31
Outcome
Met primary endpoint
paper OA+MBP before colorectal surgery significantly reduced the incidence of SSIs. PMID 37702427 ↗
paper The incidence of SSIs in the control group (27/152) was significantly higher than that in the experimental group (13/157; P =0.013) PMID 37702427 ↗
Publications
- Lei P, Jia G, Yang X, Ruan Y, Wei B, Chen T. Region-specific protection effect of preoperative oral antibiotics combined with mechanical bowel preparation before laparoscopic colorectal resection: a prospective randomized controlled trial. Int J Surg. 2023 Oct 1;109(10):3042-3051. doi: 10.1097/JS9.0000000000000569.
- Willis MA, Toews I, Soltau SL, Kalff JC, Meerpohl JJ, Vilz TO. Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective colorectal surgery. Cochrane Database Syst Rev. 2023 Feb 7;2(2):CD014909. doi: 10.1002/14651858.CD014909.pub2.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Metronidazole | Small molecule | 0.2 g | Oral |
| Subject | Neomycin | Unknown | 1 g | Oral |