Response to Clenbuterol in Humans

Summary

Due to the long half-life (\~36 hr) of clenbuterol, detection methods such as dried blood spots (DBS) are a potentially suitable method to easily and non-invasively detect doping misuse of this compound for several days after ingestion. If, and how long, the compound can be detected by DBS has not yet been investigated but is of interest due to its potential in doping-control. The aim is to evaluate whether abuse of clenbuterol can be detected at relevant concentration levels in samples obtained using DBS and to assess the physiological response to clenbuterol in skeletal muscle..

Timeline

Start

2019-03-11

Primary completion

2022-12-21

Completion

2022-12-21

Publications

• Hostrup M, Moesgaard L, Fischer M, Wickham KA, Pleshardt M, Andersen AB, Bejder J, Thomassen M, Nielsen JJ, Dehnes Y, Bangsbo J, Nordsborg NB, Jessen S. Clenbuterol induces lean mass and muscle protein accretion, but attenuates cardiorespiratory fitness and desensitizes muscle beta2-adrenergic signalling. J Physiol. 2025 Oct;603(19):5529-5545. doi: 10.1113/JP289023. Epub 2025 Sep 14.

Drugs

Indications

No indication recorded.