Uric Acid Reduction as a Novel Treatment for Pediatric Chronic Kidney Disease

Summary

Aim 1. To determine the effect of Allopurinol treatment on renal function (glomerular filtration rate, GFR) in pediatric chronic kidney disease (CKD) patients with high uric acid levels (hyperuricemia). Aim 2. Establish whether Allopurinol treatment reduces Nlrp3 inflammasome and renal injury biomarkers.

Timeline

Start

2019-03-10

Primary completion

2020-10-07

Completion

2020-10-07

Outcome

Outcome not reported

Stopped (Enrollment): “inability to achieve recruitment goals at a single center and given the current pandemic conditions”

Drugs

Indications