The Role of Neuroactive Steroids in Stress, Alcohol Craving and Alcohol Use in Alcohol Use Disorders

Summary

To use pregnenolone (PREG; 300; 500mg) daily versus placebo (PLA) as a probe to assess the role of neuroactive steroids in individuals with alcohol use disorder (AUD).

Timeline

Start

2018-09-27

Primary completion

2022-11-01

Completion

2023-08-01

Publications

• Quinlan R, Gao H, Sinha R, Milivojevic V. Effects of the neuroactive steroid precursor pregnenolone on stress- and alcohol cue-provoked pain responses in individuals with alcohol use disorder. Exp Clin Psychopharmacol. 2026 Jun 8:10.1037/pha0000862. doi: 10.1037/pha0000862. Online ahead of print.

Drugs

Indications