Treating Hyperexcitability in AD With Levetiracetam

Summary

The aim of this study is to explore the relationship between cortical hyperexcitability, abnormalities of brain network function, and cognitive dysfunction in human patients with AD and whether administration of the antiepileptic medication levetiracetam (LEV) normalizes these measures and improves cognition.

Timeline

Start

2019-08-22

Primary completion

2026-02-16

Completion

2026-02-16

Publications

• Results Ozdemir RA, Passera B, Fried PJ, Press D, Shaughnessy LW, Buss S, Shafi MM. Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer's disease. Sci Adv. 2025 Nov 28;11(48):eadt8991. doi: 10.1126/sciadv.adt8991. Epub 2025 Nov 28.
• Results Hagan B, Buss SS, Fried PJ, Shafi MM, Turk KW, Xie KY, Frank B, Passera B, Ozdemir RA, Budson AE. Evaluating Alzheimer's disease with the TMS-EEG perturbation complexity index. Neurosci Conscious. 2026 Jan 21;2026(1):niaf062. doi: 10.1093/nc/niaf062. eCollection 2026.

Drugs

Indications